منابع مشابه
Inheritance of Antibody Specificity
Our data suggest that fine specificity of antihapten antibodies is a useful Mendelian marker of variable (V) genes. We found that some mouse strains (e.g., C57/BL6) consistently produced heteroclitic anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies (relative affinity for related (4-hydroxy-5-iodo-3-nitrophenyl)acetyl and (4-hydroxy-3.5-dinitrophenyl)acetyl was always >2) while other strains...
متن کاملInheritance and drug response.
From the Departments of Molecular Pharmacology and Experimental Therapeutics and Medicine, Mayo Medical School, Mayo Clinic, and Mayo Foundation, Rochester, Minn. Address reprint requests to Dr. Weinshilboum at the Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Medical School–Mayo Clinic– Mayo Foundation, Rochester, MN 55905, or at [email protected]. he pro...
متن کاملIdiotype Expression and the Inheritance of Mouse Antibody Clones
The inheritance of idiotypes was investigated using idiotypic antisera against two monoclonal antibodies to streptococcal carbohydrates derived from A/J mice. Each of the two idiotypes was characterized by a special frequency of expression. One of the idiotypes was expressed in more than 80% of A/J mice, the other in less than 20%. The idiotypes of both antibodies were strain specific and were ...
متن کاملAntibody Response to Human Extracellular HER2 Subdomain Proteins in Mice
Background: In addition to passive immunotherapy using anti-HER2 monoclonal antibodies, active immunotherapy via HER2 targeting is an interesting approach to inducing specific anti-tumor immune responses. We have recently reported the immunogenicity of HER2 subdomains following DNA immunization and HER2 protein boosting. In the present study, we evaluated the immunogenicity of different HER2 ex...
متن کاملSelection response in traits with maternal inheritance.
Maternal inheritance is the non-Mendelian transmission of traits from mothers to their offspring. Despite its presence in virtually all organisms, acting through a variety of mechanisms, the evolutionary consequences of maternal inheritance are not well understood. Here we review and extend a model of the inheritance and evolution of multiple quantitative characters with complex pathways of mat...
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ژورنال
عنوان ژورنال: Australian Journal of Biological Sciences
سال: 1955
ISSN: 0004-9417
DOI: 10.1071/bi9550603